Tan Davin, Štrukil Vjekoslav, Mottillo Cristina, Friščić Tomislav
Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, Montreal, Canada.
Chem Commun (Camb). 2014 May 25;50(40):5248-50. doi: 10.1039/c3cc47905f. Epub 2013 Nov 20.
We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.
我们展示了机械化学在磺酰基 -（硫代）脲合成中的首次应用，通过化学计量碱辅助或铜催化的磺酰胺与异（硫代）氰酸酯的偶联反应，以良好至优异的分离产率合成了包括已知抗糖尿病药物甲苯磺丁脲、氯磺丙脲和格列本脲在内的化合物。
