肟的机械化学二聚反应生成呋咱。
Mechanochemical Dimerization of Aldoximes to Furoxans.
机构信息
Hefei National Laboratory for Physical Sciences, Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
出版信息
Molecules. 2022 Apr 18;27(8):2604. doi: 10.3390/molecules27082604.
Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions.
无溶剂机械研磨是一种新的、环保且经济高效的技术，现已广泛应用于有机合成领域。通过在氯化钠、Oxone 和碱的存在下，原位生成的腈氧化物二聚化，实现了从醛肟到呋咱的机械化学无溶剂合成。该方法以高达 92%的收率得到了多种呋咱。本方案具有反应效率高和反应条件温和的优点。
Zotero 插件