通过非对映选择性酰氧基芳基化合成二氢苯并[b]呋喃。

Synthesis of dihydrobenzo[b]furans by diastereoselective acyloxyarylation.

机构信息

Institute of Transformative Bio-Molecules (WPI-ITbM) and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.

出版信息

Chem Commun (Camb). 2014 Jan 14;50(4):463-5. doi: 10.1039/c3cc47350c.

DOI:10.1039/c3cc47350c

PMID:24257079

Abstract

A highly diastereoselective synthesis of 2-aryl-3-acyloxy-2,3-dihydrobenzofurans by palladium-catalyzed acyloxyarylation involving dearomatization of benzofurans with arylboronic acids and carboxylic acids occurring under mild conditions has been developed.

摘要

发展了一种钯催化的酰氧基芳基化反应，通过该反应可以高非对映选择性地合成 2-芳基-3-酰氧基-2,3-二氢苯并呋喃。该反应涉及苯并呋喃与芳基硼酸和羧酸在温和条件下的脱芳构化，生成酰氧基芳基化合物。