Zheng Bing-qing, Zheng Zhi
Department of Ophthalmology, First People's Hospital of Shanghai, Shanghai Jiaotong University, Shanghai 200080, China.
Zhonghua Yan Ke Za Zhi. 2013 Jul;49(7):661-4.
The biological activities of complement system, which are activated mainly through classical pathway, alternative pathway and mannose-binding lectin pathway, include cytotoxicity, bacteriolysis, sterilization, cell regulation, immune adherence, neutralization and dissolution of virus and inflammatory mediators. It is well known that diabetic retinopathy (DR) is one of the common complications of diabetes mellitus and is the leading cause of blindness among working-age adults in the developed countries and regions, but the mechanism underlying its pathogenesis is not yet fully understood. Until now, numbers of studies showed that the activation of complement system is involved in the pathogenesis of DR. Naturally, these finding paves a way for the prevention and treatment of DR in the future.
补体系统的生物活性主要通过经典途径、替代途径和甘露糖结合凝集素途径激活，包括细胞毒性、细菌溶解、杀菌、细胞调节、免疫黏附、病毒中和与溶解以及炎症介质的作用。众所周知，糖尿病视网膜病变（DR）是糖尿病的常见并发症之一，是发达国家和地区劳动年龄成年人失明的主要原因，但其发病机制尚未完全明确。到目前为止，大量研究表明补体系统的激活参与了DR的发病过程。自然地，这些发现为未来DR的防治开辟了一条道路。
