一名接受硫唑嘌呤和类固醇治疗的克罗恩病患者发生播散性皮肤单纯疱疹感染：首例报告及文献综述
Disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under azathioprine and steroids: First case report and literature review.
作者信息
Santos-Antunes João, Abreu Cândida, Magro Fernando, Coelho Rosa, Vilas-Boas Filipe, Andrade Patrícia, Lopes Susana, Macedo Guilherme
机构信息
Gastroenterology Department, Faculty of Medicine, Hospital de São João, Porto, Portugal; Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Portugal.
Department of Infectious Diseases, Faculty of Medicine, University of Porto, Portugal.
出版信息
J Crohns Colitis. 2014 Apr;8(4):326-30. doi: 10.1016/j.crohns.2013.10.011. Epub 2013 Nov 17.
Immunosuppressive treatments used in the management of Inflammatory Bowel Disease, namely steroids, thiopurines and anti-TNF drugs, raise the risk of acquiring opportunistic infections. However, most of these infections are mild and self-limited, not requiring specific therapy or suspension of the immunosuppressors. We report a case of disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under steroids and azathioprine.
用于治疗炎症性肠病的免疫抑制疗法，即类固醇、硫唑嘌呤和抗TNF药物，会增加获得机会性感染的风险。然而，这些感染大多是轻度且自限性的，不需要特殊治疗或停用免疫抑制剂。我们报告一例克罗恩病患者在使用类固醇和硫唑嘌呤治疗期间发生播散性皮肤单纯疱疹感染的病例。
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