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腺苷脱氨酶可作为二肽基肽酶 4 介导的中东呼吸综合征冠状病毒进入的天然拮抗剂。

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

机构信息

Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

出版信息

J Virol. 2014 Feb;88(3):1834-8. doi: 10.1128/JVI.02935-13. Epub 2013 Nov 20.

DOI:10.1128/JVI.02935-13
PMID:24257613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3911594/
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amino acids variable in ferret DPP4 thus revealed the functional human DPP4 virus binding site. Adenosine deaminase (ADA), a DPP4 binding protein, competed for virus binding, acting as a natural antagonist for MERS-CoV infection.

摘要

中东呼吸综合征冠状病毒（MERS-CoV）使用二肽基肽酶 4（DPP4）作为功能性受体在不同物种的细胞中复制。在这里，我们展示了雪貂对 MERS-CoV 感染的抵抗力，以及雪貂 DPP4 无法结合 MERS-CoV 的事实。因此，对氨基酸可变的雪貂 DPP4 进行定点突变，揭示了功能性人 DPP4 病毒结合位点。腺苷脱氨酶（ADA），一种 DPP4 结合蛋白，与病毒竞争结合，作为 MERS-CoV 感染的天然拮抗剂。

相似文献

[1]
Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

J Virol. 2013-11-20

[2]
A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein.

J Virol. 2014-4-9

[3]
Permissivity of Dipeptidyl Peptidase 4 Orthologs to Middle East Respiratory Syndrome Coronavirus Is Governed by Glycosylation and Other Complex Determinants.

J Virol. 2017-9-12

[4]
Adaptive Evolution of MERS-CoV to Species Variation in DPP4.

Cell Rep. 2018-8-14

[5]
Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

J Virol. 2013-9-25

[6]
Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

J Virol. 2014-6-4

[7]
Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus.

J Virol. 2016-5-12

[8]
Species-Specific Colocalization of Middle East Respiratory Syndrome Coronavirus Attachment and Entry Receptors.

J Virol. 2019-7-30

[9]
The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases.

PLoS Pathog. 2017-7-31

[10]
Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization.

J Virol. 2019-1-4

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[1]
Adenosine deaminase mediates endothelial inflammation via an ADA1-CD26 interaction in post-COVID.

Front Pharmacol. 2025-5-21

[2]
Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model.

Npj Viruses. 2024-8-21

[3]
Comprehensive transcriptomic analysis identifies cholesterol transport pathway as a therapeutic target of porcine epidemic diarrhea coronavirus.

Virus Res. 2024-12

[4]
Aprotinin (II): Inhalational Administration for the Treatment of COVID-19 and Other Viral Conditions.

Int J Mol Sci. 2024-6-29

[5]
Care, management, and use of ferrets in biomedical research.

Lab Anim Res. 2024-3-26

[6]
Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.

Virulence. 2024-12

[7]
Bat-associated microbes: Opportunities and perils, an overview.

Heliyon. 2023-11-18

[8]
Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019.

Int J Mol Sci. 2023-8-24

[9]
Dipyridamole and adenosinergic pathway in Covid-19: a juice or holy grail.

Egypt J Med Hum Genet. 2022

[10]
Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients' susceptibility to COVID-19 to the possible caution of future global diabetes tsunami.

Inflammopharmacology. 2023-6

本文引用的文献

[1]
Middle East respiratory syndrome coronavirus in bats, Saudi Arabia.

Emerg Infect Dis. 2013-11

[2]
Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody.

J Virol. 2013-9-25

[3]
Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa.

Emerg Infect Dis. 2013-10

[4]
Spiking the MERS-coronavirus receptor.

Cell Res. 2013-8-13

[5]
The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.

PLoS One. 2013-7-2

[6]
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4.

Cell Res. 2013-7-9

[7]
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.

Nature. 2013-7-7

[8]
The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

J Virol. 2013-6-19

[9]
Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation.

J Infect Dis. 2013-3-26

[10]
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.

Nature. 2013-3-14

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