Aydın Gözde Bumin, Ergil Jülide, Polat Reyhan, Sayın Murat, Akelma Fatma Kavak
Department of Anesthesiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ministry of Health, Diskapi, Ankara, Turkey.
J Anesth. 2014 Aug;28(4):494-8. doi: 10.1007/s00540-013-1749-7. Epub 2013 Nov 21.
Postoperative sore throat (POST) is a frequent complication caused by mucosal trauma to the pharyngeal, laryngeal, and tracheal airway after endotracheal intubation. We compared the effectiveness of Siccoral, Strefen, and Stomatovis treatments in alleviating POST.
This prospective, randomized, single-blinded, controlled trial compares the incidence of POST with Strefen lozenges, Siccoral spray, or Stomatovis gargle. Three hundred and twenty American Society of Anesthesiologists class I-III patients undergoing elective genitourinary surgery under general orotracheal anesthesia were randomly allocated to four groups of 80 patients each. In the postoperative awakening unit and during related services, POST was evaluated by a blinded anesthesiologist at 0, 1, 6, and 24 h post extubation.
The highest incidence of POST occured at 0 and 1 h post extubation in all groups (P = 0.002 × 10(-7), P = 0.004 × 10(-6), respectively). A significantly lower incidence of POST was observed in Strefen and Siccoral groups at 0 and 1 h compared to Control group (Strefen: P = 0.004 × 10(-2), P = 0.007 × 10(-4); Siccoral: P = 0.003 × 10(-8), P = 0.007 × 10(-5), respectively). A significantly lower incidence of POST was observed with Siccoral treatment at 0 h post extubation (P = 0.002 vs. Strefen treatment). Although POST incidence was not significantly different between the Stomatovis and Control groups, it was lower in the Stomatovis group at 0 and 1 h (P = 0.026 and 0.013, respectively). The incidence of POST was similar in all groups at 6 and 24 h post extubation (P = 0.141 and 0.426, respectively).
Siccoral and Strefen can be effective in relieving POST in the early hours after extubation.
术后咽痛（POST）是气管内插管后咽、喉和气管气道黏膜损伤引起的常见并发症。我们比较了西科拉尔（Siccoral）、斯特雷芬（Strefen）和口腔卫士（Stomatovis）治疗缓解术后咽痛的效果。
这项前瞻性、随机、单盲、对照试验比较了使用斯特雷芬含片、西科拉尔喷雾剂或口腔卫士含漱液后术后咽痛的发生率。320例美国麻醉医师协会I - III级患者在全身经口气管麻醉下接受择期泌尿生殖系统手术，随机分为四组，每组80例。在术后苏醒室及相关服务期间，由一位盲法麻醉医师在拔管后0、1、6和24小时评估术后咽痛情况。
所有组术后咽痛的最高发生率出现在拔管后0和1小时（分别为P = 0.002×10⁻⁷，P = 0.004×10⁻⁶）。与对照组相比，斯特雷芬组和西科拉尔组在0和1小时时术后咽痛的发生率显著更低（斯特雷芬组：P = 0.004×10⁻²，P = 0.007×10⁻⁴；西科拉尔组：分别为P = 0.003×10⁻⁸，P = 0.007×10⁻⁵）。拔管后0小时时，西科拉尔治疗的术后咽痛发生率显著低于斯特雷芬治疗（P = 0.002）。虽然口腔卫士组和对照组之间术后咽痛发生率无显著差异，但在0和1小时时口腔卫士组的发生率更低（分别为P = 0.026和0.013）。拔管后6和24小时时，所有组术后咽痛的发生率相似（分别为P = 0.141和0.426）。
西科拉尔和斯特雷芬在拔管后的早期能有效缓解术后咽痛。
