Metformin: are potential benefits on cancer risk extended to cancer survival?
作者信息
La Vecchia Carlo, Bosetti Cristina
机构信息
Department of Epidemiology, IRCCS-lstituto di Ricerche Farmacologiche Mario Negri, Milano, Italy;
出版信息
Oncologist. 2013;18(12):1245-7. doi: 10.1634/theoncologist.2013-0381. Epub 2013 Nov 20.
Abstract
摘要
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Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis.二甲双胍与同时患有 2 型糖尿病的癌症患者的生存获益相关：系统评价和荟萃分析。
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Increased risk of cognitive impairment in patients with diabetes is associated with metformin.糖尿病患者认知障碍风险增加与二甲双胍有关。
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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.双胍类药物通过减少环 AMP 的产生来抑制肝胰高血糖素信号。
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