Department of Medicine, The Queen's University Belfast, The Institute of Clinical Science, Grosvenor Road, Belfast.
Biol Trace Elem Res. 1985 Jun;7(4):241-53. doi: 10.1007/BF02989249.
Two methods of intestinal perfusion are described and used to study the effecs of alcohol on zinc absorption in the rat small intestine. The first method used perfusion of the lumen of the rat small intestinein situ without interruption of the vascular supply. During perfusion with a zinc-containing medium (with and without alcohol), alcohol was found to have no effect on net zinc uptake from the lumen of the intestine. However, there were significantly higher serum zinc concentrations recorded in the rats perfused wih the zinc and alcohol, 28.8 μmol/L, when compared with a group perfused without alcohol, 19.1 μmol/L (P < 0.01). The second method used simultaneous perfusion of the lumen of the rat small intestine, with constant-rate perfusion of the vascular bed with an artificial blood supply. In this experiment with a zinc-containing medium, with and without alcohol, there was no difference noted in zinc absorption from the lumen of the intestine, or release into the artificial blood supply. Therefore, in conclusion, alcohol does not appear to directly influence zinc absorption by the mucosal cells of the small intestine.
两种肠道灌注方法被描述并用于研究酒精对大鼠小肠锌吸收的影响。第一种方法是在不中断血管供应的情况下原位灌注大鼠小肠腔。在含有锌的介质（含酒精和不含酒精）的灌注过程中，发现酒精对肠腔中锌的净摄取没有影响。然而，与未灌注酒精的大鼠相比，灌注锌和酒精的大鼠血清锌浓度显著升高，分别为 28.8 μmol/L 和 19.1 μmol/L（P < 0.01）。第二种方法是同时用人工血液供应恒速灌注大鼠小肠腔和血管床。在这个含有锌的介质的实验中，无论是否含有酒精，从肠腔吸收锌或释放到人工血液供应中都没有差异。因此，总之，酒精似乎并没有直接影响小肠黏膜细胞对锌的吸收。
