胆汁形成的生理和分子生化机制。
Physiological and molecular biochemical mechanisms of bile formation.
机构信息
Vasiliy Ivanovich Reshetnyak, V.A. Negovsky Scientific Research Institute of General Reanimatology, Russian Academy of Medical Sciences, 107031 Moscow, Russia.
出版信息
World J Gastroenterol. 2013 Nov 14;19(42):7341-60. doi: 10.3748/wjg.v19.i42.7341.
Abstract
This review considers the physiological and molecular biochemical mechanisms of bile formation. The composition of bile and structure of a bile canaliculus, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micellar structures, and enterohepatic circulation of bile acids are described. In general, the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract.
摘要
这篇综述探讨了胆汁形成的生理和分子生化机制。描述了胆汁的组成和胆小管的结构、胆汁酸的生物合成和共轭、胆汁磷脂、胆汁胶束结构的形成以及胆汁酸的肠肝循环。总的来说，该综述侧重于肝细胞窦状和顶膜转运系统的分子生理学。对胆汁形成的生理和生化基础的了解对于理解与肝脏和胆道疾病相关的病理过程的机制具有重要意义。
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