来自海洋真菌曲霉菌的阿普拉内酯A及一类新的立体化学类弯孢霉菌素
Apralactone A and a New Stereochemical Class of Curvularins from the Marine-Derived Fungus sp.
作者信息
Greve Hendrik, Schupp Peter J, Eguereva Ekaterina, Kehraus Stefan, Kelter Gerhard, Maier Armin, Fiebig Heinz-Herbert, König Gabriele M
机构信息
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
出版信息
European J Org Chem. 2008 Oct;2008(30). doi: 10.1002/ejoc.200800522.
Abstract
Chemical investigations of the cytotoxic extract of the marine-derived fungus sp. (strain no. 768), isolated from the red alga , yielded the novel macrolide apralactone A (), as well as the antipodes of curvularin macrolides . Compound , a dimeric curvularin was recognised as an artefact. The structures of were elucidated by interpretation of their spectroscopic data (1D and 2D NMR, CD, MS, UV and IR). Apralactone A () is a 14-membered phenyl acetic acid macrolactone, and the first such compound with a 4-chromanone substructure. Compounds and were found to be cytotoxic towards human tumor cell lines with mean IC values in the range of 1.25 to 30.06 µM.
摘要
对从红藻中分离出的海洋来源真菌sp.（菌株编号768）的细胞毒性提取物进行化学研究，得到了新型大环内酯类化合物阿普拉内酯A（），以及弯孢菌素大环内酯类化合物的对映体。化合物，一种二聚体弯孢菌素被认为是一种人工产物。通过对它们的光谱数据（一维和二维核磁共振、圆二色光谱、质谱、紫外光谱和红外光谱）进行解释，阐明了的结构。阿普拉内酯A（）是一种14元苯基乙酸大环内酯，是第一个具有4-色满酮亚结构的此类化合物。发现化合物和对人肿瘤细胞系具有细胞毒性，平均IC值在1.25至30.06 μM范围内。
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