曲霉色酮A和B，从与海洋海绵相关的真菌曲霉属菌株SCSIO XWS03F03中分离得到的两种新型聚酮化合物。

Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus Aspergillus sp. SCSIO XWS03F03.

作者信息

Wang Ying, Lin Xiu-Ping, Ju Zhi-Ran, Liao Xiao-Jian, Huang Xiao-Jun, Zhang Chen, Zhao Bing-Xin, Xu Shi-Hai

机构信息

a Department of Chemistry , Jinan University , Guangzhou 510632 , China.

b Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , China.

出版信息

J Asian Nat Prod Res. 2017 Jul;19(7):684-690. doi: 10.1080/10286020.2016.1231673. Epub 2016 Sep 26.

DOI:10.1080/10286020.2016.1231673

PMID:28276769

Abstract

Two new polyketides, aspergchromones A (1) and B (2), together with five known compounds, secalonic acid D (3), noreugenin (4), (3S)-5-hydroxymellein (5), (4S)-6-hydroxyisosclerone (6), and (-)-regiolone (7), were isolated from the ethyl acetate extract of marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound 3 showed moderate antimicrobial activity.

摘要

从海洋海绵来源的真菌曲霉属SCSIO XWS03F03的乙酸乙酯提取物中分离出两种新的聚酮化合物，曲霉色酮A（1）和B（2），以及五种已知化合物，secalonic酸D（3）、去甲丁香色原酮（4）、（3S）-5-羟基水片盘菌素（5）、（4S）-6-羟基异硬皮酮（6）和（-）-区域酮（7）。通过光谱技术（一维和二维核磁共振、质谱、紫外和红外）阐明了它们的结构。通过电子圆二色性计算确定了新化合物的绝对构型。化合物3表现出中等抗菌活性。