来自内生真菌漆斑菌的细胞毒性单端孢霉烯大环内酯类化合物。
Cytotoxic trichothecene macrolides from the endophyte fungus Myrothecium roridum.
作者信息
Liu Hong-Xin, Liu Wei-Zhen, Chen Yu-Chan, Sun Zhang-Hua, Tan Yu-Zhi, Li Hao-Hua, Zhang Wei-Min
机构信息
a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou , China.
b College of Pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.
出版信息
J Asian Nat Prod Res. 2016 Jul;18(7):684-9. doi: 10.1080/10286020.2015.1134505. Epub 2016 Jan 21.
A new cytotoxic roridin-type trichothecene macrolide named epiroridin acid (1) and two known compounds epiroridin E (2) and mytoxin B (3) were isolated from the liquid culture of Myrothecium roridum A553, which was isolated from the medicinal plant Pogostemon cablin. The structure of the new macrolide (1) was elucidated by extensive spectroscopic measurements (UV, IR, MS, and 1D and 2D NMR) analyses. All isolated compounds (1-3) were evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 tumor cell lines. The new compound (1) exhibited well cytotoxicity against the four selected tumor cell lines.
从药用植物广藿香中分离得到的米根霉A553的液体培养物中，分离出一种名为表roridin酸（1）的新型细胞毒性roridin型单端孢霉烯大环内酯以及两种已知化合物表roridin E（2）和霉菌毒素B（3）。通过广泛的光谱测量（紫外、红外、质谱以及一维和二维核磁共振）分析阐明了新型大环内酯（1）的结构。对所有分离出的化合物（1-3）针对SF-268、MCF-7、NCI-H460和HepG-2肿瘤细胞系的细胞毒性活性进行了评估。新化合物（1）对四种选定的肿瘤细胞系表现出良好的细胞毒性。
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