Seyyednejad Farshad, Rezaee Amirreza, Haghi Sarvar, Goldust Mohamad
Department of Radiotherapy, Tabriz University of Medical Sciences, Tabriz, Iran.
Pak J Biol Sci. 2012 Nov 15;15(22):1098-101. doi: 10.3923/pjbs.2012.1098.1101.
Mucositis is a toxic side effect of anti-cancer treatments and is a major focus in cancer research. Pro-inflammatory cytokines have previously been implicated in the pathophysiology of chemotherapy-induced mucositis. The aim of this study was to detect a correlation between serum cytokine levels in head and neck (H and N) cancer patients receiving combined chemo-radiation therapy. Thirty patients with H and N epithelial cancer were recruited to this study. All patients received radiotherapy to the H and N region with doses ranging from 50-70 Gray (Gy). Chemotherapy with cisplatin, carboplatin, 5-fluorouracil and taxanes was given to high-risk patients, using standard chemotherapy protocols. Patients were evaluated for mucositis according to WHO common toxicity criteria and blood samples were drawn for inflammatory (IL-1 and TNF-a) and before and during treatment. The mucositis evaluation demonstrated mucositis grade IV in 33.3% of the patients after the 3rd treatment week. At the end of treatment, the number of patients with grade IV mucositis was less. IL-1 and TNF-alpha did not show any correlation with PEG tube installation. The level of cytokines measured before and during therapy showed decreased TNF-alpha especially after the third week of therapy. No relationship between IL-1 and TNF-alpha, level and mucositis grade was shown.
黏膜炎是抗癌治疗的一种毒性副作用，也是癌症研究的主要焦点。促炎细胞因子先前已被认为与化疗引起的黏膜炎的病理生理学有关。本研究的目的是检测接受联合放化疗的头颈癌患者血清细胞因子水平之间的相关性。30名头颈上皮癌患者被纳入本研究。所有患者均接受头颈区域放疗，剂量范围为50-70格雷（Gy）。高危患者采用标准化疗方案，给予顺铂、卡铂、5-氟尿嘧啶和紫杉烷化疗。根据世界卫生组织常见毒性标准对患者进行黏膜炎评估，并在治疗前和治疗期间采集血样检测炎症因子（IL-1和TNF-α）。黏膜炎评估显示，在第3个治疗周后，33.3%的患者出现IV级黏膜炎。治疗结束时，IV级黏膜炎患者数量减少。IL-1和TNF-α与PEG管置入无任何相关性。治疗前和治疗期间检测的细胞因子水平显示TNF-α水平下降，尤其是在治疗第三周后。未显示IL-1和TNF-α水平与黏膜炎分级之间的关系。
