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Cutaneous basophil (Jones-Mote) hypersensitivity after "tolerogenic" doses of intravenous ovalbumin in the guinea pig.

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The role of the reticuloendothelial system in the host reaction to neoplasia.

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结核菌素型与琼斯-莫特型超敏反应之间的关系：分枝杆菌佐剂对嗜碱性粒细胞浸润的抑制作用。

Relationship between the tuberculin-type and Jones-Mote-type hypersensitivities: suppression of basophil infiltration by mycobacterial adjuvant.

作者信息

Nakamura S, Sanui H, Nomoto K

出版信息

Immunology. 1986 Jul;58(3):397-403.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453475/

Abstract

Guinea-pigs immunized with bovine gammaglobulin (BGG) in incomplete Freund's adjuvant (IFA) showed the typical Jones-Mote-type hypersensitivity (JMH) reaction when tested 5 days later. This is characterized by prominent basophil infiltration. After pretreatment with complete Freund's adjuvant (CFA) 16 days before immunization with BGG in IFA, the lesions resembled the JMH reaction macroscopically in their evolution over time and in the absence of a positive macrophage migration inhibition (MIT) test. However, histologically, the lesions resembled classical tuberculin-type hypersensitivity with prominent mononuclear cell infiltration without any basophils. The pretreated animals, which failed to show basophil infiltration, were able to transfer JMH reactions with basophil infiltration into normal animals. In contrast, pretreatment of recipients with CFA or Corynebacterium parvum prevented the passive transfer of the characteristic effect on the JMH reaction when given shortly before skin testing. We postulate that macrophages activated by CFA may play an important role in regulating basophil infiltration in the effector phase of the delayed hypersensitivity reaction.

摘要

用牛γ球蛋白（BGG）在不完全弗氏佐剂（IFA）中免疫的豚鼠，在5天后进行检测时表现出典型的琼斯-莫特型超敏反应（JMH）。其特征是有明显的嗜碱性粒细胞浸润。在用BGG于IFA中免疫前16天用完全弗氏佐剂（CFA）预处理后，随着时间推移，病变在宏观上的演变以及在巨噬细胞移动抑制（MIT）试验呈阴性的情况下，类似于JMH反应。然而，在组织学上，病变类似于经典的结核菌素型超敏反应，有明显的单核细胞浸润，没有任何嗜碱性粒细胞。未显示嗜碱性粒细胞浸润的预处理动物能够将伴有嗜碱性粒细胞浸润的JMH反应转移到正常动物体内。相反，在皮肤试验前不久给受体用CFA或微小棒状杆菌预处理，可阻止对JMH反应的特征性效应的被动转移。我们推测，由CFA激活的巨噬细胞可能在迟发型超敏反应效应阶段调节嗜碱性粒细胞浸润中起重要作用。