不同龋病状态儿童唾液总分泌型免疫球蛋白A（SIgA）与变形链球菌特异性SIgA的相关性
Correlation of total salivary secretory immunoglobulin A (SIgA) and mutans specific SIgA in children having different caries status.
作者信息
Pal Soumen, Mitra Malay, Mishra Jiban, Saha Subrata, Bhattacharya Bhaswar
机构信息
Department of Pedodontics and Preventive Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.
出版信息
J Indian Soc Pedod Prev Dent. 2013 Oct-Dec;31(4):270-4. doi: 10.4103/0970-4388.121831.
BACKGROUND
Relation between secretory immunoglobulin A (SigA) and dental caries still imprecise. Studies have been conducted either for total SIgA or mutans specific SIgA with bizarre results.
AIM
The aim of this study is to find out the relationship between mutans antigen specific SIgA and total salivary SIgA and its influence in caries status in children.
MATERIALS AND METHODS
A total of 45 children aged between 6-14 years were divided based on their caries index (decayed, missing, filled, extracted tooth) score in high moderate and no caries group and their saliva were analyzed with enzyme linked immunosorbent assay for total SIgA and mutans specific SIgA.
RESULTS
High caries group showed high mutans specific SIgA, but less total SIgA, whereas low caries group showed the reverse.
CONCLUSION
The mutans specific SIgA and total SIgA has a weak, but negative correlation in children potentiating caries inhibitory action of SIgA.
背景
分泌型免疫球蛋白A（SigA）与龋齿之间的关系仍不明确。已开展的研究针对的要么是总分泌型免疫球蛋白A，要么是变形链球菌特异性分泌型免疫球蛋白A，结果令人费解。
目的
本研究旨在探究变形链球菌抗原特异性分泌型免疫球蛋白A与唾液总分泌型免疫球蛋白A之间的关系及其对儿童龋齿状况的影响。
材料与方法
根据龋病指数（龋、失、补、拔牙）得分，将45名6至14岁儿童分为高龋组、中度龋组和无龋组，并采用酶联免疫吸附测定法分析其唾液中的总分泌型免疫球蛋白A和变形链球菌特异性分泌型免疫球蛋白A。
结果
高龋组的变形链球菌特异性分泌型免疫球蛋白A含量高，但总分泌型免疫球蛋白A含量低，而低龋组则相反。
结论
在儿童中，变形链球菌特异性分泌型免疫球蛋白A与总分泌型免疫球蛋白A存在弱负相关，增强了分泌型免疫球蛋白A的防龋作用。
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