Rose P T, Gregory R L, Gfell L E, Hughes C V
Department of Oral Microbiology, Goldman School of Graduate Dentistry, Boston University Medical Center, Massachusetts.
Pediatr Dent. 1994 Jul-Aug;16(4):272-5.
Previous studies have shown a positive correlation between salivary IgA antibody levels to Streptococcus mutans and caries resistance in adults. In this study, enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels with S. mutans in whole and parotid saliva from 20 caries-susceptible (CS; DMFS > 5) and 20 caries-resistant (CR; DMFS < or = 1) children (aged 7-11 years). Whole salivary S. mutans numbers were significantly greater (P < or = 0.05) in the CS group (mean of 31.2% of total oral streptococci) than in the CR group (mean of 1.6% of total oral streptococci). Whole saliva, but not parotid saliva, from CR children had significantly higher (P < or = 0.05) levels of IgA antibodies to S. mutans than saliva from CS children. These results suggest that salivary IgA antibodies to S. mutans may play a role in natural protection from dental caries in children and that the source of increased salivary IgA antibody in CR children may be either the minor, submandibular, or sublingual salivary glands.
以往研究表明，成人唾液中抗变形链球菌IgA抗体水平与龋齿抵抗力呈正相关。在本研究中，采用酶联免疫吸附测定法（ELISA）比较了20名易感龋（CS；DMFS>5）儿童和20名抗龋（CR；DMFS≤1）儿童（7-11岁）全唾液和腮腺唾液中抗变形链球菌IgA抗体水平。CS组全唾液中变形链球菌数量显著高于CR组（P≤0.05）（平均占口腔链球菌总数的31.2%）（CR组平均占口腔链球菌总数的1.6%）。CR儿童的全唾液而非腮腺唾液中，抗变形链球菌IgA抗体水平显著高于CS儿童的唾液（P≤0.05）。这些结果表明，唾液中抗变形链球菌IgA抗体可能在儿童预防龋齿的天然保护中发挥作用，并且CR儿童唾液中IgA抗体增加的来源可能是小唾液腺、下颌下腺或舌下腺。
