Ducatelle R, Maenhout D, Coussement W, Hoorens J K
J Comp Pathol. 1986 Jul;96(4):433-45. doi: 10.1016/0021-9975(86)90039-3.
The relation of myofibrillar hypoplasia to clinical splayleg was studied. A strain of Belgian Landrace sows was selected for this study because they produced pigs which had no myofibrillar hypoplasia. Myofibrillar hypoplasia could nevertheless by induced experimentally in these animals by dexamethasone treatment of the sows during late pregnancy. The lesion was observed without clinical signs and was compared to the myofibrillar hypoplasia in clinical cases of splayleg. The differences between these 2 groups may account for the appearance of clinical signs. These differences included the maturity of the myofibrils and the degree of autophagolysosomal glycogen breakdown.
研究了肌原纤维发育不全与临床八字腿之间的关系。本研究选用了一批比利时长白母猪，因为它们所产仔猪没有肌原纤维发育不全的情况。然而，在妊娠后期给这些母猪注射地塞米松可通过实验诱导出肌原纤维发育不全。观察到该病变时并无临床症状，并将其与临床八字腿病例中的肌原纤维发育不全进行了比较。这两组之间的差异可能是临床症状出现的原因。这些差异包括肌原纤维的成熟度以及自噬溶酶体糖原分解的程度。
