正常志愿者和味觉嗅觉功能障碍患者红细胞膜中的锌浓度。

Zinc concentration in erythrocyte membranes in normal volunteers and in patients with taste and smell dysfunction.

机构信息

Center for Molecular Nutrition and Sensory Disorders, Georgetown University Medical Center, 20007, Washington, DC.

出版信息

Biol Trace Elem Res. 1983 Feb;5(1):1-8. doi: 10.1007/BF02916921.

Abstract

Erythrocyte membrane zinc concentration was measured in 14 normal volunteers and in 36 patients with taste and smell dysfunction, and compared with zinc concentration in erythrocyte cytosol and blood plasma in the normal volunteers and with zinc concentration in erythrocyte cytosol, blood serum, urine, and parotid saliva in the patients. A A significant negative correlation was found between age and membrane zinc concentration in the normals. A significant positive correlation was found between parotid saliva zinc and erythrocyte membrane zinc concentrations in the patients. Concentration of zinc in the erythrocyte membrane is 50% greater than its concentration in cytosol, and three times greater than the zinc concentration in plasma or serum; membrane zinc concentration in humans is approximately one-half that reported in the dog or in the mouse.

摘要

红细胞膜锌浓度在 14 名正常志愿者和 36 名味觉和嗅觉功能障碍患者中进行了测量，并与正常志愿者的红细胞胞浆和血浆中的锌浓度以及患者的红细胞胞浆、血清、尿液和腮腺唾液中的锌浓度进行了比较。正常组中年龄与膜锌浓度呈显著负相关。患者的腮腺唾液锌与红细胞膜锌浓度呈显著正相关。红细胞膜中的锌浓度比胞浆中的锌浓度高 50%，比血浆或血清中的锌浓度高 3 倍；人类红细胞膜中的锌浓度约为狗或鼠报道的一半。