Riviere Y, Oldstone M B
J Virol. 1986 Aug;59(2):363-8. doi: 10.1128/JVI.59.2.363-368.1986.
Reassortant viruses of different strains of lymphocytic choriomeningitis viruses cause lethal disease after inoculation into neonatal BALB/c WEHI mice, but, in contrast, parental strains or reciprocal reassortants do not cause lethal disease. The disease is characterized by inhibition of growth and death. The pathogenic mechanism is the induction of interferon combined with higher virus titers and subsequent liver necrosis. The generation of lethal reassortants from nonlethal parent viruses likely has implications for understanding the outbreaks of unanticipated virulent disease within a viral family.
不同株淋巴细胞性脉络丛脑膜炎病毒的重配病毒接种新生BALB/c WEHI小鼠后会引发致死性疾病，但相比之下，亲代毒株或反向重配病毒不会引发致死性疾病。该疾病的特征为生长抑制和死亡。致病机制是干扰素的诱导，同时伴有较高的病毒滴度及随后的肝坏死。由非致死性亲代病毒产生致死性重配病毒可能对理解病毒家族内意外出现的烈性疾病暴发具有重要意义。
