Rivière Y, Gresser I, Guillon J C, Tovey M G
Proc Natl Acad Sci U S A. 1977 May;74(5):2135-9. doi: 10.1073/pnas.74.5.2135.
Inoculation of newborn mice with lymphocytic chloriomeningitis (LCM) virus resulted in decreased weight gain, liver cell necrosis, and death. Injection of potent sheep immunoglobulin against mouse interferon markedly inhibited these manifestations of LCM virus disease despite the fact that these treated mice had 100-fold more LCM virus in their serum. We conclude that interferon induced by LCM virus is responsible in large part for the syndrome of growth inhibition, liver cell necrosis, and death observed in LCM virus-infected suckling mice.
给新生小鼠接种淋巴细胞性脉络丛脑膜炎（LCM）病毒会导致体重增加减缓、肝细胞坏死和死亡。注射高效抗小鼠干扰素的绵羊免疫球蛋白能显著抑制LCM病毒病的这些表现，尽管这些接受治疗的小鼠血清中的LCM病毒含量高出100倍。我们得出结论，LCM病毒诱导产生的干扰素在很大程度上导致了LCM病毒感染的乳鼠出现生长抑制、肝细胞坏死和死亡综合征。
