Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Srinagar, India.
Org Biomol Chem. 2014 Jan 14;12(2):242-6. doi: 10.1039/c3ob41847b.
An efficient and expeditious DABCO-mediated synthesis of functionalized enamides from alkenes is delineated. The reaction proceeds through an unprecedented cascade involving an Aza-Michael addition/α-bromination/elimination and a Morita-Baylis-Hillman type reaction to generate functionalized enamides in a regio- & stereoselective fashion.
本文描述了一种高效、快速的 DABCO 介导的由烯烃合成功能化烯酰胺的方法。该反应通过前所未有的级联反应进行，包括 Aza-Michael 加成/α-溴化/消除和 Morita-Baylis-Hillman 型反应，以区域和立体选择性的方式生成功能化烯酰胺。
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