有机催化的对映选择性 N-烯丙基酰胺不对称烷基化反应。
Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Chem Commun (Camb). 2011 Apr 28;47(16):4784-6. doi: 10.1039/c0cc05616b. Epub 2011 Mar 16.
PMID:21409282
Abstract
The first Lewis base-catalysed chemoselective asymmetric N-allylic alkylation of enamides with Morita-Baylis-Hillman carbonates has been developed, which affords multifunctional products in moderate to high enantioselectivity (up to 92% ee).
摘要
首次发展了路易斯碱催化的酰胺与 Morita-Baylis-Hillman 碳酸酯的对映选择性 N-烯丙基烷基化反应，该反应以中等至较高的对映选择性（高达 92%ee）得到多功能产物。
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