Mei Szu-Chieh, Brenner Charles
Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Chem Biol. 2013 Nov 21;20(11):1307-8. doi: 10.1016/j.chembiol.2013.11.001.
Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.
通过高通量化学和基因筛选，马西尼及其同事（在本期《化学生物学》中）确定烟酰胺磷酸核糖基转移酶抑制剂STF-118804是一种对伴有MLL染色体重排的混合谱系白血病具有细胞类型特异性的抑制剂。该方法很有效，NAD作为一种特定癌症靶点的潜力也是如此。
