可卡因成瘾的不寻常嫌疑人。
An unusual suspect in cocaine addiction.
机构信息
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
出版信息
Neuron. 2013 Nov 20;80(4):835-6. doi: 10.1016/j.neuron.2013.11.001.
Abstract
Development of drug addiction is extremely complex, but its initiation can be as simple as the flip-flop of glutamatergic receptor subtypes triggered by an "unusual" type of NMDA receptors, as suggested by Yuan et al. (2013) in this issue of Neuron.
摘要
药物成瘾的发展极其复杂，但正如袁等人（2013）在本期《神经元》杂志中所提出的，其起始可能非常简单，只需 NMDA 受体的“异常”类型引发的谷氨酸能受体亚型的翻转即可。
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Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.通过 mGluR1 正变构调节的突触抑制可抑制线索诱导的可卡因渴求。
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Neuron. 2013 Nov 20;80(4):1025-38. doi: 10.1016/j.neuron.2013.07.050. Epub 2013 Oct 31.
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Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving.杏仁核-伏隔核投射中的沉默突触的成熟有助于可卡因渴望的潜伏期。
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