Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt am Main, Germany; Donders Centre for Brain, Cognition, and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands; Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Neuron. 2013 Nov 20;80(4):1077-89. doi: 10.1016/j.neuron.2013.08.019.
Selective visual attention is subserved by selective neuronal synchronization, entailing precise orchestration among excitatory and inhibitory cells. We tentatively identified these as broad (BS) and narrow spiking (NS) cells and analyzed their synchronization to the local field potential in two macaque monkeys performing a selective visual attention task. Across cells, gamma phases scattered widely but were unaffected by stimulation or attention. During stimulation, NS cells lagged BS cells on average by ∼60° and gamma synchronized twice as strongly. Attention enhanced and reduced the gamma locking of strongly and weakly activated cells, respectively. During a prestimulus attentional cue period, BS cells showed weak gamma synchronization, while NS cells gamma-synchronized as strongly as with visual stimulation. These analyses reveal the cell-type-specific dynamics of the gamma cycle in macaque visual cortex and suggest that attention affects neurons differentially depending on cell type and activation level.
选择性视觉注意受选择性神经元同步支配，需要兴奋和抑制细胞之间的精确协调。我们初步将这些细胞鉴定为宽（BS）和窄峰（NS）细胞，并在两只执行选择性视觉注意任务的猕猴中分析了它们对局部场电位的同步性。跨细胞的伽马相位分布广泛，但不受刺激或注意的影响。在刺激期间，NS 细胞平均滞后 BS 细胞约 60°，伽马同步强度强两倍。注意分别增强和降低了强激活和弱激活细胞的伽马锁定。在刺激前注意线索期，BS 细胞表现出较弱的伽马同步，而 NS 细胞的伽马同步与视觉刺激一样强。这些分析揭示了猕猴视觉皮层中伽马周期的细胞类型特异性动力学，并表明注意根据细胞类型和激活水平对神经元产生不同的影响。
