Andersen Mie, Hirase Hajime, Kjaerby Celia, Nedergaard Maiken
Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA.
Curr Opin Neurol. 2025 Aug 1;38(4):298-305. doi: 10.1097/WCO.0000000000001392. Epub 2025 Jun 5.
Gamma oscillations (30-80 Hz) play a crucial role in sensory processing and cognitive functions, with disruptions in these rhythms linked to neurological disorders such as schizophrenia and Alzheimer's disease. This review highlights the emerging role of astrocytes in regulating gamma oscillations, emphasizing their contribution to the inhibitory tone and extracellular ion homeostasis.
Recent studies suggest that astrocytes facilitate gamma synchrony, while dysfunction in astrocytic activity - such as impaired Ca 2+ signaling - is associated with deficits in gamma oscillations and increased network hyperexcitability. Thus, astrocytic dysfunction may contribute to the pathophysiology of gamma-related disorders.
By examining the role of astrocytes in maintaining neuronal network stability, this review highlights new aspects of neuroglia signaling.
γ振荡（30 - 80赫兹）在感觉处理和认知功能中起着关键作用，这些节律的紊乱与精神分裂症和阿尔茨海默病等神经系统疾病有关。本综述强调了星形胶质细胞在调节γ振荡中的新作用，重点关注它们对抑制性张力和细胞外离子稳态的贡献。
最近的研究表明，星形胶质细胞促进γ同步，而星形胶质细胞活动功能障碍，如钙信号受损，与γ振荡缺陷和网络兴奋性增加有关。因此，星形胶质细胞功能障碍可能导致与γ相关疾病的病理生理过程。
通过研究星形胶质细胞在维持神经元网络稳定性中的作用，本综述突出了神经胶质信号传导的新方面。
