Wornom I L, Smith J W, Soong S J, McElvein R, Urist M M, Balch C M
Ann Surg. 1986 Aug;204(2):181-5. doi: 10.1097/00000658-198608000-00013.
Sixty-five patients with distant metastatic melanoma amenable to surgical treatment had excision of 94 metastatic lesions from the brain, lung, abdomen, distant subcutaneous sites, and distant lymph nodes. Relief of symptoms, if present, was obtained after excision of 77% of brain metastases, 100% of lung metastases, 88% of distant lymph node and subcutaneous metastases, and 100% of abdominal metastases. Median survival after excision of brain metastases was 8 months, lung metastases 9 months, abdominal metastases 8 months, and distant subcutaneous and lymph node metastases 15 months. Sixteen per cent of patients lived for 2 years of longer. These results demonstrated that surgery can achieve an effective local disease control in selected patients with distant melanoma metastases and that a few have a relatively long-term survival.
65例适合手术治疗的远处转移性黑色素瘤患者接受了手术，切除了来自脑、肺、腹部、远处皮下部位和远处淋巴结的94个转移病灶。如果存在症状，切除77%的脑转移灶、100%的肺转移灶、88%的远处淋巴结和皮下转移灶以及100%的腹部转移灶后症状得到缓解。切除脑转移灶后的中位生存期为8个月，肺转移灶为9个月，腹部转移灶为8个月，远处皮下和淋巴结转移灶为15个月。16%的患者存活了2年或更长时间。这些结果表明，手术可以在部分远处黑色素瘤转移患者中实现有效的局部疾病控制，并且少数患者有相对长期的生存。
