Galicich J H, Sundaresan N, Arbit E, Passe S
Cancer. 1980 Jan 15;45(2):381-6. doi: 10.1002/1097-0142(19800115)45:2<381::aid-cncr2820450232>3.0.co;2-j.
The results of surgical excision of solitary intracerebral metastases followed by whole-brain radiation therapy between 1972 and 1978 in a series of 78 patients were analyzed. The overall median survival of the series was 6 months with a 1-year survival rate of 29%. Statistical analyses of the data revealed that patients who presented with a cerebral metastasis 1 year or more after diagnosis of the primary cancer had a significantly longer survival than those in whom the metastasis was detected within 1 year (P less than .04). Patients with mild or no neurological deficits at time of craniotomy had a longer median survival and a 1-year survival of 44% (P less than .01). The presence of metastases at one or two other sites did not significantly affect overall survival except in those patients in whom the brain metastasis was detected more than 1 year after diagnosis of the primary tumor. Factors found to affect survival in this study may be useful in predicting survival of future patients similarly treated.
对1972年至1978年间接受手术切除孤立性脑转移瘤并随后进行全脑放疗的78例患者的结果进行了分析。该系列患者的总体中位生存期为6个月，1年生存率为29%。数据的统计分析显示，在原发性癌症诊断后1年或更长时间出现脑转移的患者，其生存期明显长于在1年内检测到转移的患者（P小于0.04）。开颅手术时神经功能缺损较轻或无神经功能缺损的患者，中位生存期较长，1年生存率为44%（P小于0.01）。在一个或两个其他部位存在转移，除了那些在原发性肿瘤诊断后1年以上才检测到脑转移的患者外，对总体生存期没有显著影响。在本研究中发现的影响生存的因素可能有助于预测未来接受类似治疗的患者的生存情况。
