靶向鼻腔接种提供了针对金黄色葡萄球菌的抗体非依赖性保护。
Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.
机构信息
Adjuvant Research Group.
出版信息
J Infect Dis. 2014 May 1;209(9):1479-84. doi: 10.1093/infdis/jit636. Epub 2013 Nov 22.
Abstract
Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus.
摘要
尽管在临床前模型中显示出前景，但抗金黄色葡萄球菌疫苗在临床试验中失败了。迄今为止，方法主要集中在中和/调理抗体上；然而，尚未研究专门诱导细胞免疫的疫苗，以正式测试细胞免疫反应是否可以预防感染。我们证明，用靶向载有金黄色葡萄球菌抗原的纳米颗粒进行鼻腔接种可以在没有任何抗原特异性抗体的情况下预防急性全身性金黄色葡萄球菌感染。这些发现可以帮助为葡萄球菌疫苗开发的未来发展以及对金黄色葡萄球菌保护性免疫要求的研究提供信息。
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2
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3
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4
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PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191.
6
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9
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