Deptartment of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Science, Warsaw, Poland.
World J Surg Oncol. 2013 Nov 25;11:302. doi: 10.1186/1477-7819-11-302.
Surgical wounds in cancer patients have a relatively high dehiscence rate. Although colon cancer resections are performed so as to include macroscopically non-involved tissues, some cancer cells can be present in the line of transection. The local healing process may facilitate proliferation of these localized cancer cells and the high cytokine concentration within the healing wound may also attract cancer cells from distant sites to migrate into the wound area. The growing tumor cells may then stretch the wound, hampering its contraction process.
The aim of the study was to monitor and compare, using immunohistochemical methods, the healing process of intestinal anastomosis in both normal rats and in rats with disseminated cancer (the CC531 colon cancer model).
There was a significantly higher rate of anastomotic dehiscence in the group of rats with disseminated cancer, than in the group of normal rats. There were no significant differences between the two groups in the levels of mononuclear wound infiltration or of formation of connective tissue or new vessels. All anastomotic wounds in animals with disseminated cancer had abundant infiltrates of both migrating and proliferating cancer cells.
We confirmed that the environment of a healing wound attracts cancer cells. Migration of cancer cells to the wound and centrifugal cancer proliferation may adversely affect the healing process and cause wound disruption.
癌症患者的手术切口有相对较高的裂开率。虽然结肠癌切除术是为了包括宏观上无受累的组织，但在切缘处可能存在一些癌细胞。局部愈合过程可能促进这些局部癌细胞的增殖，而愈合伤口内的高细胞因子浓度也可能吸引来自远处部位的癌细胞迁移到伤口区域。生长的肿瘤细胞可能会拉伸伤口，阻碍其收缩过程。
本研究的目的是使用免疫组织化学方法监测和比较正常大鼠和播散性癌症大鼠（CC531 结肠癌模型）的肠吻合口愈合过程。
播散性癌症大鼠组的吻合口裂开率明显高于正常大鼠组。两组单核细胞伤口浸润程度或结缔组织和新血管形成无显著差异。所有播散性癌症大鼠的吻合口均有大量迁移和增殖的癌细胞浸润。
我们证实了愈合伤口的环境会吸引癌细胞。癌细胞向伤口迁移和离心性癌细胞增殖可能会对愈合过程产生不利影响，并导致伤口破裂。
