Department of Chemical and Biological Engineering, University of Colorado Boulder , Boulder, Colorado 80309, United States.
ACS Appl Mater Interfaces. 2013 Dec 26;5(24):12854-9. doi: 10.1021/am405280w. Epub 2013 Dec 6.
Many fields of research have adopted self-assembly of colloidal spheres as an easy and reliable method to produce macroscopic structures with nanoscale periodicity. The field of soft lithography in particular has used colloidal self-assembly to fabricate lithographic masks and templates. We developed a colloidal lithography method that uses the colloidal assembly directly to produce submicrometer topographic and chemical surface patterns. The method does not require any specialized equipment, making it particularly useful in biological and chemical laboratories without lithography expertise. The technique involves the curing and solvent removal of a self-assembled colloidal crystal from an inorganic surface. The result is a triangular array of polymer features with submicrometer periodicity that covers square centimeters of surface area. The feature size and spacing is easily controlled, and the features serve as reactive sites for biomolecule immobilization.
许多研究领域已经采用胶体球的自组装作为一种简单可靠的方法来制备具有纳米级周期性的宏观结构。特别是软光刻领域已经使用胶体自组装来制造光刻掩模和模板。我们开发了一种胶体光刻方法，该方法直接使用胶体组装来产生亚微米级的形貌和化学表面图案。该方法不需要任何特殊设备，因此在没有光刻专业知识的生物和化学实验室中特别有用。该技术涉及从无机表面固化和去除自组装胶体晶体。结果是得到一个具有亚微米周期性的三角形聚合物特征阵列，其覆盖平方厘米的表面积。特征尺寸和间距很容易控制，并且这些特征可以作为生物分子固定化的反应位点。
