• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肝供体活检中的人类疱疹病毒 6 和巨细胞病毒 DNA 及其与 HLA 配型和急性细胞排斥的相关性。

Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection.

机构信息

Faculty of Medical Science, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.

Unit of Liver Transplantation, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.

出版信息

Braz J Infect Dis. 2014 Mar-Apr;18(2):220-4. doi: 10.1016/j.bjid.2013.07.007. Epub 2013 Nov 22.

DOI:10.1016/j.bjid.2013.07.007
PMID:24275367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9427445/
Abstract

UNLABELLED

Herpesvirus reactivation is common after liver transplantation.

OBJECTIVE

Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection.

METHODS

Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied.

RESULTS

Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p=0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p=0.03; χ(2)=4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p=0.08).

CONCLUSION

HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation.

摘要

未标注

肝移植后疱疹病毒再激活很常见。

目的

分析肝供体活检中巨细胞病毒（CMV）和人类疱疹病毒-6（HHV-6）DNA 的存在情况，以期更好地了解与人类供体白细胞抗原（HLA）-A、B 和 DR 相关的问题，以及与急性细胞排斥的相关性。

方法

使用巢式 PCR 技术，对 59 例肝移植患者肝供体活检中 CMV 和 HHV-6 DNA 的存在情况进行了调查。临床供体信息和 HLA 匹配情况从圣保罗州移植系统获得。研究了受者关于急性细胞排斥的记录。

结果

7 例（11.8%）活检标本 CMV DNA 阳性，29 例（49%）HHV-6 DNA 阳性。在 14 例 HLA-DR 15 阳性的供体中，有 9 例肝活检 HHV-6 DNA 阳性，存在显著相关性的趋势（p=0.09），22 例受者发生急性细胞排斥，9/22 例 HLA-DR 15 阳性（p=0.03；χ²=4.51），单因素分析有统计学意义，多因素分析后呈趋势（p=0.08）。

结论

在所研究的肝供体中，HHV-6 DNA 与 HLA-DR 15 均较常见。这些发现表明，肝供体活检中 HLA-DR 15 的患者在肝移植后发生排斥反应的可能性更大。

相似文献

1
Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection.肝供体活检中的人类疱疹病毒 6 和巨细胞病毒 DNA 及其与 HLA 配型和急性细胞排斥的相关性。
Braz J Infect Dis. 2014 Mar-Apr;18(2):220-4. doi: 10.1016/j.bjid.2013.07.007. Epub 2013 Nov 22.
2
Detection of cytomegalovirus and human herpesvirus-6 DNA in liver biopsy specimens and their correlation with rejection after liver transplantation.肝活检标本中巨细胞病毒和人疱疹病毒6型DNA的检测及其与肝移植后排斥反应的相关性。
Transplant Proc. 2012 Oct;44(8):2441-4. doi: 10.1016/j.transproceed.2012.07.027.
3
Co-infection and clinical impact of human herpesvirus 5 and 6 in liver transplantation.人疱疹病毒5型和6型在肝移植中的合并感染及临床影响
Transplant Proc. 2012 Oct;44(8):2455-8. doi: 10.1016/j.transproceed.2012.07.034.
4
Human herpesvirus 6 in donor biopsies associated with the incidence of clinical cytomegalovirus disease and hepatitis C virus recurrence.供体活检中的人类疱疹病毒 6 与临床巨细胞病毒病和丙型肝炎病毒复发的发生率有关。
Int J Infect Dis. 2012 Feb;16(2):e124-9. doi: 10.1016/j.ijid.2011.10.008. Epub 2011 Dec 16.
5
Simultaneous monitoring of CMV and human herpesvirus 6 infections and diseases in liver transplant patients: one-year follow-up.肝移植患者巨细胞病毒和人类疱疹病毒 6 感染和疾病的同步监测：一年随访。
Clinics (Sao Paulo). 2011;66(6):949-53. doi: 10.1590/s1807-59322011000600005.
6
Simultaneous monitoring by real-time polymerase chain reaction of epstein-barr virus, human cytomegalovirus, and human herpesvirus-6 in juvenile and adult liver transplant recipients.实时聚合酶链反应同时监测青少年和成人肝移植受者中的爱泼斯坦-巴尔病毒、人巨细胞病毒和人疱疹病毒6型
Transplant Proc. 2008 Dec;40(10):3578-82. doi: 10.1016/j.transproceed.2008.05.082.
7
Cytomegalovirus, human herpesvirus-6, and human herpesvirus-7 in adult liver transplant recipients: diagnosis based on antigenemia.成年肝移植受者中的巨细胞病毒、人类疱疹病毒6型和人类疱疹病毒7型：基于抗原血症的诊断
Transplant Proc. 2011 May;43(4):1357-9. doi: 10.1016/j.transproceed.2011.03.062.
8
Human cytomegalovirus early infection, acute rejection, and major histocompatibility class II expression in transplanted lung. Molecular, immunocytochemical, and histopathologic investigations.人巨细胞病毒早期感染、急性排斥反应及移植肺中主要组织相容性复合体II类分子的表达。分子、免疫细胞化学及组织病理学研究。
Transplantation. 1996 Feb 15;61(3):418-27. doi: 10.1097/00007890-199602150-00018.
9
beta-Herpesvirus (human cytomegalovirus and human herpesvirus 6) reactivation in at-risk lung transplant recipients and in human immunodeficiency virus-infected patients.β疱疹病毒（人巨细胞病毒和人疱疹病毒6型）在高危肺移植受者和人类免疫缺陷病毒感染患者中的再激活。
J Infect Dis. 2002 Jul 15;186(2):173-80. doi: 10.1086/341456. Epub 2002 Jun 17.
10
High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis.肝内 HHV-6 病毒载量高，但巨细胞病毒和 EBV 与移植肝炎诊断后的移植物存活率降低无关。
J Hepatol. 2012 May;56(5):1063-1069. doi: 10.1016/j.jhep.2011.12.017. Epub 2012 Jan 13.

引用本文的文献

1
Post liver transplant recurrent and de novo viral infections.肝移植后复发和新发病毒感染。
Best Pract Res Clin Gastroenterol. 2020 Jun-Aug;46-47:101689. doi: 10.1016/j.bpg.2020.101689. Epub 2020 Sep 26.
2
Optimisation of a quantitative polymerase chain reaction-based strategy for the detection and quantification of human herpesvirus 6 DNA in patients undergoing allogeneic haematopoietic stem cell transplantation.基于定量聚合酶链反应的策略优化，用于检测和定量接受异基因造血干细胞移植患者的人疱疹病毒6型DNA
Mem Inst Oswaldo Cruz. 2015 Jun;110(4):461-7. doi: 10.1590/0074-02760150004. Epub 2015 Jun 2.

本文引用的文献

1
Co-infection and clinical impact of human herpesvirus 5 and 6 in liver transplantation.人疱疹病毒5型和6型在肝移植中的合并感染及临床影响
Transplant Proc. 2012 Oct;44(8):2455-8. doi: 10.1016/j.transproceed.2012.07.034.
2
Detection of cytomegalovirus and human herpesvirus-6 DNA in liver biopsy specimens and their correlation with rejection after liver transplantation.肝活检标本中巨细胞病毒和人疱疹病毒6型DNA的检测及其与肝移植后排斥反应的相关性。
Transplant Proc. 2012 Oct;44(8):2441-4. doi: 10.1016/j.transproceed.2012.07.027.
3
Cytomegalovirus in solid organ transplantation: epidemiology, prevention, and treatment.巨细胞病毒在实体器官移植中的：流行病学、预防和治疗。
Curr Infect Dis Rep. 2012 Dec;14(6):633-41. doi: 10.1007/s11908-012-0292-2.
4
High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis.肝内 HHV-6 病毒载量高，但巨细胞病毒和 EBV 与移植肝炎诊断后的移植物存活率降低无关。
J Hepatol. 2012 May;56(5):1063-1069. doi: 10.1016/j.jhep.2011.12.017. Epub 2012 Jan 13.
5
Human herpesvirus 6 in donor biopsies associated with the incidence of clinical cytomegalovirus disease and hepatitis C virus recurrence.供体活检中的人类疱疹病毒 6 与临床巨细胞病毒病和丙型肝炎病毒复发的发生率有关。
Int J Infect Dis. 2012 Feb;16(2):e124-9. doi: 10.1016/j.ijid.2011.10.008. Epub 2011 Dec 16.
6
Association of human cytomegalovirus viremia with human leukocyte antigens in liver transplantation recipients.肝移植受者人巨细胞病毒血症与人类白细胞抗原的相关性。
Acta Biochim Biophys Sin (Shanghai). 2011 Jul;43(7):576-81. doi: 10.1093/abbs/gmr043. Epub 2011 Jun 16.
7
Monitoring and detection of cytomegalovirus in liver transplant recipients.肝移植受者中巨细胞病毒的监测与检测
Transplant Proc. 2011 May;43(4):1360-1. doi: 10.1016/j.transproceed.2011.02.031.
8
Impact of human herpes virus 6 in liver transplantation.人疱疹病毒6型在肝移植中的影响。
World J Hepatol. 2010 Sep 27;2(9):345-53. doi: 10.4254/wjh.v2.i9.345.
9
Impact of human leukocyte antigen mismatching on outcomes of liver transplantation: a meta-analysis.人类白细胞抗原错配对肝移植结局的影响：荟萃分析。
World J Gastroenterol. 2010 Jul 21;16(27):3457-64. doi: 10.3748/wjg.v16.i27.3457.
10
Human herpesvirus 6 infections after liver transplantation.肝移植后的人疱疹病毒6型感染
World J Gastroenterol. 2009 Jun 7;15(21):2561-9. doi: 10.3748/wjg.15.2561.