Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Curr Infect Dis Rep. 2012 Dec;14(6):633-41. doi: 10.1007/s11908-012-0292-2.
Cytomegalovirus (CMV) is one of the most important pathogens that infect solid organ transplant recipients. CMV is associated with increased morbidity and mortality in this population as a result of its numerous direct and indirect effects. Prevention strategies consist of preemptive therapy and antiviral prophylaxis, and the choice of which preventive approach to implement should be guided by advantages and drawbacks related to the population being managed. There are differences in the approaches to the laboratory diagnosis and treatment of CMV infection and disease depending on assay availability, clinical presentation, disease severity, and specific transplant populations. In this article, the authors aim to summarize recent publications and updates in the epidemiology, diagnosis, prevention, and treatment of CMV infection in solid organ transplant recipients during the past year, including a brief review of future directions in the field.
巨细胞病毒（CMV）是感染实体器官移植受者的最重要病原体之一。由于其众多直接和间接影响，CMV 导致该人群发病率和死亡率增加。预防策略包括抢先治疗和抗病毒预防，应根据所管理人群的优缺点来指导选择实施哪种预防方法。根据检测方法的可用性、临床表现、疾病严重程度和特定移植人群，CMV 感染和疾病的实验室诊断和治疗方法存在差异。本文作者旨在总结过去一年中实体器官移植受者 CMV 感染的流行病学、诊断、预防和治疗方面的最新出版物和更新，包括该领域未来方向的简要回顾。
