Silhol M, Huez G, Lebleu B
J Gen Virol. 1986 Sep;67 ( Pt 9):1867-73. doi: 10.1099/0022-1317-67-9-1867.
The direct introduction with micropipettes of poly(rI).poly(rC) into the cytoplasm of several human cell lines inhibited the multiplication of vesicular stomatitis virus. This antiviral activity was at least partly due to interferon (IFN) production and secretion from the injected cells since it was species-specific, partly neutralized by IFN antibodies and was transmissible to non-adjacent cells. This suggests a mechanism of IFN induction involving the internalization of poly(rI).poly(rC) and its interaction with an intracellular target.
用微量移液器将聚肌苷酸-聚胞苷酸（poly(rI).poly(rC)）直接导入几种人类细胞系的细胞质中，可抑制水疱性口炎病毒的增殖。这种抗病毒活性至少部分归因于注射细胞产生并分泌干扰素（IFN），因为它具有种属特异性，部分被IFN抗体中和，并且可传递给不相邻的细胞。这提示了一种IFN诱导机制，涉及poly(rI).poly(rC)的内化及其与细胞内靶点的相互作用。
