School of Chemical Engineering and Material Science, Chung-Ang University, 47 Heukseok-ro, Dongjak-gu, Seoul, 156-756, Korea.
Arch Pharm Res. 2014 Jan;37(1):79-87. doi: 10.1007/s12272-013-0289-x. Epub 2013 Nov 26.
Drug efficacy has been improved using various methods that enhance targeting, decrease toxicity, and facilitate timely and sustained drug release. To achieve these properties, various drug loading and release platforms have been developed. Layer-by-layer (LbL) self-assembly is widely used to generate controlled and sustained drug release LbL multilayer films because it allows desired functions and structures to be obtained through a simple procedure. In this review article, we highlight controlled drug release from LbL self-assembling films with diverse release kinetics, particularly with regard to mechanisms of drug release.
已经使用各种方法来提高药物疗效，这些方法包括增强靶向性、降低毒性以及促进药物的及时和持续释放。为了实现这些特性，已经开发了各种药物负载和释放平台。层层自组装（LbL）被广泛用于生成可控和持续药物释放的 LbL 多层膜，因为它可以通过简单的程序获得所需的功能和结构。在这篇综述文章中，我们重点介绍了具有不同释放动力学的 LbL 自组装膜的药物控制释放，特别是涉及药物释放机制的内容。
