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局部感染在银屑病和慢性荨麻疹发病机制中的作用。

The role of focal infections in the pathogenesis of psoriasis and chronic urticaria.

作者信息

Brzewski Paweł Łukasz, Spałkowska Magdalena, Podbielska Magdalena, Chmielewska Joanna, Wołek Marta, Malec Katarzyna, Wojas-Pelc Anna

机构信息

Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland. Head: Prof. Anna Wojas-Pelc MD, PhD.

出版信息

Postepy Dermatol Alergol. 2013 Apr;30(2):77-84. doi: 10.5114/pdia.2013.34155. Epub 2013 Apr 12.

Abstract

INTRODUCTION

The Focal Infection Theory, originally presented at the beginning of the 20(th) century, postulates that systemic diseases can be caused by microorganisms that arise from the focus of infection. Foci of infections have been described as sinuses, adenoids, tonsils, teeth, genitourinary tract, gall bladder and kidneys. A focus of infection is defined as the area that can occur in any part of the body, contains a pathogen (microorganism) and is usually asymptomatic. There are discordant opinions about the role of focal infections in the pathogenesis of psoriasis and urticaria.

AIM

To establish whether there is a higher incidence of focal infections in patients with chronic urticaria and psoriasis.

MATERIAL AND METHODS

We retrospectively reviewed 129 patients with a history of psoriasis and chronic urticaria: 58 women and 71 men treated in the Department of Dermatology of the Jagiellonian University Medical College in Krakow.

RESULTS

In the analyzed group, 11 patients had a dental consultation, 58 - laryngological consultation and 29 women had a gynecological consultation. The most common examples of focal infection were tonsillitis, upper respiratory tract infections, sinusitis, dental caries and genitourinary tract infections. Aggravating factors were similar to previously described.

CONCLUSIONS

A high incidence of focal infections in patients with psoriasis and urticaria suggests that infections may play a significant role in the pathogenesis of these skin disorders. Treatment of infection foci may play the key role in the remission of skin changes.

摘要

引言

病灶感染理论最初于20世纪初提出,该理论假定全身性疾病可由感染病灶产生的微生物引起。感染病灶已被描述为鼻窦、腺样体、扁桃体、牙齿、泌尿生殖道、胆囊和肾脏。感染病灶被定义为可出现在身体任何部位、含有病原体(微生物)且通常无症状的区域。关于病灶感染在银屑病和荨麻疹发病机制中的作用存在不同观点。

目的

确定慢性荨麻疹和银屑病患者中病灶感染的发生率是否更高。

材料与方法

我们回顾性分析了129例有银屑病和慢性荨麻疹病史的患者:58例女性和71例男性,均在克拉科夫雅盖隆大学医学院皮肤科接受治疗。

结果

在分析的患者组中,11例患者进行了牙科会诊,58例进行了耳鼻喉科会诊,29例女性进行了妇科会诊。病灶感染最常见的例子是扁桃体炎、上呼吸道感染、鼻窦炎、龋齿和泌尿生殖道感染。加重因素与先前描述的相似。

结论

银屑病和荨麻疹患者中病灶感染的高发生率表明,感染可能在这些皮肤疾病的发病机制中起重要作用。治疗感染病灶可能在皮肤病变缓解中起关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a721/3834683/b3c10744eb77/PDIA-30-20465-g001.jpg

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