Reader T A, Brière R, Grondin L, Ferron A
Neurochem Res. 1986 Jul;11(7):1025-35. doi: 10.1007/BF00965591.
The catecholamines noradrenaline, dopamine, adrenaline, the indoleamine 5-hydroxy-tryptamine (5-HT; serotonin), and some of their major metabolites were assayed, using high performance liquid chromatography (HPLC), in the neocortex of normal rats as well as in animals in which 5-HT synthesis had been inhibited with p-chlorophenylalanine. Besides important depletions in serotonin and in 5-hydroxyindole-3-acetic acid, noradrenaline levels were significantly reduced, but the content in 3-methoxy-4-hydroxyphenylglycol was increased, indicating an augmented utilization of this amine. The levels of dopamine and 3-methoxytyramine were also reduced, although homovanillic acid and 3,4-dihydroxyphenylacetic acid levels remained constant. The spontaneous unitary activity of identified noradrenergic neurons in the Locus coeruleus was increased, indicating an hyperactivity of this system. These results can be interpreted in relation to functional interactions between the catecholamines and serotonin; i.e.: a decrease in endogenous serotonin results in the loss of a negative feedback control of noradrenaline release.
使用高效液相色谱法（HPLC）测定了正常大鼠新皮质以及用对氯苯丙氨酸抑制5-羟色胺合成的动物体内儿茶酚胺类物质去甲肾上腺素、多巴胺、肾上腺素、吲哚胺5-羟色胺（5-HT；血清素）及其一些主要代谢产物。除了血清素和5-羟吲哚-3-乙酸显著减少外，去甲肾上腺素水平也明显降低，但3-甲氧基-4-羟基苯乙二醇的含量增加，表明该胺类物质的利用增加。多巴胺和3-甲氧基酪胺的水平也降低，尽管高香草酸和3,4-二羟基苯乙酸的水平保持不变。蓝斑中已鉴定的去甲肾上腺素能神经元的自发单位活动增加，表明该系统活动亢进。这些结果可以根据儿茶酚胺和血清素之间的功能相互作用来解释，即：内源性血清素的减少导致去甲肾上腺素释放的负反馈控制丧失。
