Teixeira-Mendonça Carina, Henriques-Coelho Tiago
Faculty of Medicine of Porto University, 4202-451 Porto, Portugal.
Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal; Department of Pediatric Surgery, Centro Hospitalar São João, Porto, Portugal.
Rev Port Cardiol. 2013 Dec;32(12):1005-12. doi: 10.1016/j.repc.2013.06.010. Epub 2013 Nov 23.
Failure of the normal cardiopulmonary transition can lead to persistent pulmonary hypertension of the newborn. Some degree of pulmonary hypertension complicates the course of more than 10% of all neonates with respiratory failure. This review article discusses the vascular abnormalities associated with neonatal pulmonary hypertension. Common therapies including inhaled nitric oxide, high frequency ventilation, surfactant, and extracorporeal life support are included. Promising new treatment approaches like phosphodiesterase inhibition and cell-targeted therapies are presented.
正常心肺转换失败可导致新生儿持续性肺动脉高压。在所有呼吸衰竭的新生儿中，超过10%的患儿病程会并发一定程度的肺动脉高压。这篇综述文章讨论了与新生儿肺动脉高压相关的血管异常情况。还包括了常用治疗方法，如吸入一氧化氮、高频通气、表面活性剂和体外生命支持。文中还介绍了一些有前景的新治疗方法，如磷酸二酯酶抑制和细胞靶向治疗。
