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The TRP4 gene of Saccharomyces cerevisiae: isolation and structural analysis.

作者信息

Furter R, Paravicini G, Aebi M, Braus G, Prantl F, Niederberger P, Hütter R

出版信息

Nucleic Acids Res. 1986 Aug 26;14(16):6357-73. doi: 10.1093/nar/14.16.6357.

DOI:10.1093/nar/14.16.6357
PMID:2428012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC311651/
Abstract

The TRP4 gene of Saccharomyces cerevisiae, encoding the anthranilate phosphoribosyl transferase, was isolated and subcloned by functional complementation in yeast. A 2 kb fragment containing information for a polypeptide of 380 amino acids and the 5'- and 3'-flanking regions was sequenced. The TRP4 transcript was identified and mapped with S1 nuclease. Homologies to two prokaryotic genes encoding the same function, and sequences potentially involved in transcription start and termination and in regulation of TRP4 gene expression are discussed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/07894a9d6e29/nar00285-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/f8b8a25e5d39/nar00285-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/52d1f83fefb6/nar00285-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/1949930db451/nar00285-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/07894a9d6e29/nar00285-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/f8b8a25e5d39/nar00285-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/52d1f83fefb6/nar00285-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/1949930db451/nar00285-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cf2/311651/07894a9d6e29/nar00285-0035-a.jpg

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1
The TRP4 gene of Saccharomyces cerevisiae: isolation and structural analysis.
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2
Regulation of the TRP4 gene of Saccharomyces cerevisiae at the transcriptional level and functional analysis of its promotor.酿酒酵母TRP4基因在转录水平的调控及其启动子的功能分析
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Cloning of the STA2 and SGA genes encoding glucoamylases in yeasts and regulation of their expression by the STA10 gene of Saccharomyces cerevisiae.酵母中编码葡糖淀粉酶的STA2和SGA基因的克隆以及酿酒酵母STA10基因对其表达的调控。
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Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase.酿酒酵母ADE4编码磷酸核糖焦磷酸酰胺转移酶的谷氨酰胺核苷酸序列。
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Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail.用锤头状核酶替换酵母TRP4 3'非翻译区会产生一种稳定且能有效输出的缺乏聚腺苷酸尾的mRNA。
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Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha.多形汉逊酵母中编码甲醇氧化酶基因的分子克隆与特性分析
Nucleic Acids Res. 1985 May 10;13(9):3063-82. doi: 10.1093/nar/13.9.3063.

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Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail.用锤头状核酶替换酵母TRP4 3'非翻译区会产生一种稳定且能有效输出的缺乏聚腺苷酸尾的mRNA。
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Sequence requirements of the bidirectional yeast TRP4 mRNA 3'-end formation signal.

本文引用的文献

1
Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
J Biol Chem. 1956 Jan;218(1):97-106.
2
Biological role of the general control of amino acid biosynthesis in Saccharomyces cerevisiae.酿酒酵母中氨基酸生物合成全局调控的生物学作用。
Mol Cell Biol. 1981 Jul;1(7):584-93. doi: 10.1128/mcb.1.7.584-593.1981.
3
Codon selection in yeast.酵母中的密码子选择
双向酵母TRP4 mRNA 3'端形成信号的序列要求。
Nucleic Acids Res. 1997 Jan 15;25(2):417-22. doi: 10.1093/nar/25.2.417.
4
Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae.酿酒酵母中编码双功能谷氨酰胺酰胺转移酶：环化酶的HIS7基因的克隆、一级结构及调控
J Bacteriol. 1993 Sep;175(17):5548-58. doi: 10.1128/jb.175.17.5548-5558.1993.
5
Saturation mutagenesis of a polyadenylation signal reveals a hexanucleotide element essential for mRNA 3' end formation in Saccharomyces cerevisiae.聚腺苷酸化信号的饱和诱变揭示了酿酒酵母中mRNA 3'末端形成所必需的六核苷酸元件。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):257-61. doi: 10.1073/pnas.91.1.257.
6
Messenger RNA 3'-end formation of a DNA fragment from the human c-myc 3'-end region in Saccharomyces cerevisiae.酿酒酵母中来自人类c-myc 3'-末端区域的DNA片段的信使核糖核酸3'-末端形成
Curr Genet. 1993 Mar;23(3):201-4. doi: 10.1007/BF00351496.
7
A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated.酿酒酵母纺锤体多聚体中的一种间隔蛋白，其转录本受细胞周期调控。
J Cell Biol. 1993 Dec;123(5):1175-84. doi: 10.1083/jcb.123.5.1175.
8
Regulation of the TRP4 gene of Saccharomyces cerevisiae at the transcriptional level and functional analysis of its promotor.酿酒酵母TRP4基因在转录水平的调控及其启动子的功能分析
Mol Gen Genet. 1988 Jan;211(1):168-75. doi: 10.1007/BF00338409.
9
A consensus transcription termination sequence in the promoter region is necessary for efficient gene expression of the TRP1 gene of Saccharomyces cerevisiae.启动子区域中的一个共有转录终止序列对于酿酒酵母TRP1基因的高效基因表达是必需的。
Mol Gen Genet. 1988 Jun;212(3):495-504. doi: 10.1007/BF00330855.
10
Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae.酿酒酵母中氨基酸生物合成一般调控中的基因调控机制。
Microbiol Rev. 1988 Jun;52(2):248-73. doi: 10.1128/mr.52.2.248-273.1988.
J Biol Chem. 1982 Mar 25;257(6):3026-31.
4
Attenuation in the control of expression of bacterial operons.细菌操纵子表达调控中的衰减作用。
Nature. 1981 Feb 26;289(5800):751-8. doi: 10.1038/289751a0.
5
Nucleotide sequence of the Bacillus subtilis trpE and trpD genes.枯草芽孢杆菌色氨酸E和色氨酸D基因的核苷酸序列。
Gene. 1984 Jan;27(1):55-65. doi: 10.1016/0378-1119(84)90238-5.
6
A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast.酵母通用控制系统调控HIS4所必需的一段短核苷酸序列。
Cell. 1983 Jan;32(1):89-98. doi: 10.1016/0092-8674(83)90499-3.
7
Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase.酿酒酵母中编码双功能邻氨基苯甲酸合酶：吲哚 - 3 - 甘油磷酸合酶的TRP2和TRP3基因的核苷酸序列。
J Biol Chem. 1984 Mar 25;259(6):3985-92.
8
One-step gene disruption in yeast.酵母中的一步基因破坏
Methods Enzymol. 1983;101:202-11. doi: 10.1016/0076-6879(83)01015-0.
9
Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae.HIS1上游的重复DNA序列也出现在酿酒酵母中其他几个共同调控的基因处。
J Biol Chem. 1983 Apr 25;258(8):5238-47.
10
Construction, replication, and chromatin structure of TRP1 RI circle, a multiple-copy synthetic plasmid derived from Saccharomyces cerevisiae chromosomal DNA.TRP1 RI 环的构建、复制及染色质结构，TRP1 RI 环是一种源自酿酒酵母染色体 DNA 的多拷贝合成质粒。
Mol Cell Biol. 1982 Mar;2(3):221-32. doi: 10.1128/mcb.2.3.221-232.1982.