Nowakowska E, Chodera A, Szczawińska K, Cenajek D
Pol J Pharmacol Pharm. 1986 Mar-Apr;38(2):143-8.
Cerebral concentrations of neurotransmitters: noradrenaline, dopamine, serotonin and GABA were assayed in male Wistar rats receiving either a single dose of pethidine, or a prolonged treatment with the drug (twice daily for 21 days, im), leading to tolerance development. In tolerant rats the GABA content in the cerebral tissue was increased, and the activity of serotonergic system (assessed from the changes in 5-hydroxyindoleacetic acid level and serotonin turnover rate) was augmented.
对雄性Wistar大鼠的大脑神经递质浓度进行了测定：这些大鼠分别接受了单次剂量的哌替啶，或长期使用该药物（每天两次，共21天，腹腔注射），从而产生耐受性。在产生耐受性的大鼠中，脑组织中的γ-氨基丁酸（GABA）含量增加，并且血清素能系统的活性（根据5-羟吲哚乙酸水平和血清素周转率的变化进行评估）增强。
