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啮齿动物疟疾中脑内神经递质的变化。

Changes in brain neurotransmitters in rodent malaria.

作者信息

Roy S, Chattopadhyay R N, Maitra S K

机构信息

Department of Physiology with Community Development, Vidyasagar University, Midnapore, India.

出版信息

Indian J Malariol. 1993 Dec;30(4):183-5.

PMID:7913449
Abstract

Changes in brain neurotransmitters [5-hydroxytryptamine (5-HT), norepinephrine, histamine and dopamine] were studied in Plasmodium berghei-infected mice and rats. 5-HT and norepinephrine contents of brain decreased significantly in Plasmodium berghei-infected mice and rats, but histamine and dopamine contents remained unaltered. Decreased 5-HT and norepinephrine contents of brain may play a role in cerebral vasodilatation in malaria.

摘要

在感染伯氏疟原虫的小鼠和大鼠中研究了脑神经递质[5-羟色胺(5-HT)、去甲肾上腺素、组胺和多巴胺]的变化。感染伯氏疟原虫的小鼠和大鼠脑中5-HT和去甲肾上腺素含量显著降低,但组胺和多巴胺含量未发生改变。脑中5-HT和去甲肾上腺素含量降低可能在疟疾的脑血管扩张中起作用。

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