Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico 70124, Bari, Italy.
Cancers (Basel). 2010 Feb 25;2(1):114-32. doi: 10.3390/cancers2010114.
Angiogenesis occurs in pathological conditions, such as tumors, where a specific critical point in tumor progression is the transition from the avascular to the vascular phase. Tumor angiogenesis depends mainly on the release by neoplastic cells of growth factors specific for endothelial cells, which are able to stimulate the growth of the host's blood vessels. This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described.
血管生成发生在病理条件下，如肿瘤，其中肿瘤进展的一个特定关键点是从无血管到血管阶段的转变。肿瘤血管生成主要取决于肿瘤细胞释放特定于内皮细胞的生长因子，这些生长因子能够刺激宿主血管的生长。本文总结了有关血管生成与人类黑色素瘤进展之间关系的文献。还描述了最近应用抗血管生成药物来干扰黑色素瘤进展的情况。
