Department of Geriatrics/Radboud Alzheimer Centre, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands.
PLoS One. 2013 Nov 25;8(11):e79797. doi: 10.1371/journal.pone.0079797. eCollection 2013.
To evaluate the cost-effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared to general practitioners' care.
A multicentre randomised trial with 175 community dwelling patients newly diagnosed with mild to moderate dementia, and their informal caregivers, with twelve months' follow-up. Cost-effectiveness was evaluated from a societal point of view and presented as incremental cost per quality adjusted life year. To establish cost-effectiveness, a cost-utility analysis was conducted using utilities based on the EQ-5D. Uncertainty surrounding the incremental cost-effectiveness ratio (difference in costs divided by difference in effects) was calculated by bootstrapping from the original data.
Compared to general practitioners' care, treatment by the memory clinics was on average €1024 (95% CI: -€7723 to €5674) cheaper, and showed a non-significant decrease of 0.025 (95% CI: -0.114 to 0.064) quality adjusted life years. The incremental cost-effectiveness point estimate from the bootstrap simulation was € 41 442 per QALY lost if one would use memory clinic care instead of general practitioner care.
No evidence was found that memory clinics were more cost-effective compared to general practitioners with regard to post-diagnosis treatment and coordination of care of patients with dementia in the first year after diagnosis.
ClinicalTrials.gov NCT00554047.
评估与全科医生的护理相比,记忆诊所对诊断后痴呆症的治疗和护理协调的成本效益。
这是一项多中心随机试验,纳入了 175 名新诊断为轻度至中度痴呆的社区居住患者及其非专业照顾者,随访时间为 12 个月。从社会角度评估成本效益,并以每质量调整生命年的增量成本表示。为了确定成本效益,使用基于 EQ-5D 的效用进行成本效用分析。使用原始数据进行自举法计算增量成本效益比(成本差异除以效果差异)的不确定性。
与全科医生的护理相比,记忆诊所的治疗平均节省了 1024 欧元(95%置信区间:-7723 至 5674 欧元),并且在质量调整生命年方面显示出非显著下降了 0.025(95%置信区间:-0.114 至 0.064)。自举模拟的增量成本效益点估计值为,如果使用记忆诊所护理代替全科医生护理,每失去一个质量调整生命年的成本为 41442 欧元。
在诊断后第一年,没有证据表明记忆诊所在痴呆症患者的治疗和护理协调方面比全科医生更具成本效益。
ClinicalTrials.gov NCT00554047。