利雅得地区地中海贫血和镰状细胞病患儿的乙肝和甲肝标志物

Hepatitis B and A markers in children with thalassaemia and sickle-cell disease in Riyadh.

作者信息

Babiker M A, Bahakim H M, el-Hazmi M A

出版信息

Ann Trop Paediatr. 1986 Mar;6(1):59-62. doi: 10.1080/02724936.1986.11748412.

DOI:10.1080/02724936.1986.11748412

Abstract

Sera from 40 children with beta-thalassaemia major, 54 children with sickle-cell disease and 120 matched controls were examined by radio-immunoassay for hepatitis B and A markers. The overall prevalence of hepatitis B virus markers was highest in children with thalassaemia followed by children with sickle-cell disease and lowest in the control group. The hepatitis A marker showed a reversed pattern, being lowest in the thalassaemic group. The high incidence of hepatitis B infection was presumably due to frequent blood transfusions, frequent exposure to hospital environment and the high carrier rate in the community. Frequent blood transfusions, however, seem to protect against hepatitis A virus infection.

摘要

采用放射免疫分析法对40名重型β地中海贫血患儿、54名镰状细胞病患儿及120名匹配的对照儿童的血清进行了乙肝和甲肝标志物检测。乙肝病毒标志物的总体患病率在患地中海贫血的儿童中最高，其次是患镰状细胞病的儿童，在对照组中最低。甲肝标志物呈现相反的模式，在地中海贫血组中最低。乙肝感染的高发生率可能是由于频繁输血、频繁接触医院环境以及社区中的高携带率。然而，频繁输血似乎能预防甲型肝炎病毒感染。