多次输血的地中海贫血患者甲型和乙型肝炎感染的患病率
Prevalence of hepatitis A and B infections in multiply transfused thalassaemic patients.
作者信息
Papaevangelou G, Frösner G, Economidou J, Parcha S, Roumeliotou A
出版信息
Br Med J. 1978 Mar 18;1(6114):689-91. doi: 10.1136/bmj.1.6114.689.
Abstract
Evidence of hepatitis B virus (HBV) and hepatitis A virus (HAV) infections was south in 148 multiply transfused patients with thalassaemia and in healthy controls (2040 for HBV and 217 for HAV). The prevalence of the HBV surface antigen or antibody to it was significantly higher in patients than in controls and increased with the number of blood transfusions. In contrast, the prevalence of antibody to HAV was significantly lower in patients than in controls and decreased with the number of blood transfusions. These results support the view that blood transfusion does not play any appreciable part in transmitting HAV. Indeed, regular blood transfusion, where donors almost all have HAV antibody, seems to give protection against infection.
摘要
在148例多次输血的地中海贫血患者以及健康对照者（乙肝病毒检测2040例，甲肝病毒检测217例）中，检测了乙肝病毒（HBV）和甲肝病毒（HAV）感染情况。患者中乙肝表面抗原或其抗体的流行率显著高于对照组，且随输血次数增加而升高。相反，患者中甲肝病毒抗体的流行率显著低于对照组，且随输血次数减少。这些结果支持以下观点：输血在传播甲肝病毒方面不起任何显著作用。实际上，在几乎所有献血者都有甲肝病毒抗体的情况下进行定期输血，似乎能提供感染防护。
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