镰状细胞贫血患儿乙肝标志物发病率增加。
Increased incidence of hepatitis B markers in children with sickle-cell anemia.
作者信息
Abiodun P O, Fatunde O J, Flach K H, Buck T
机构信息
Department of Child Health, College of Medical Sciences, University of Benin, Nigeria.
出版信息
Blut. 1989 Mar;58(3):147-50. doi: 10.1007/BF00320435.
Screening of 143 children 6 months to 12 years of age with sickle-cell anemia showed that 39.2% were HBsAg-positive as compared with 19.3% of the 161 control children of the same age group, who had Hb genotype AA (chi 2 = 14.7383; P less than 0.001). Fifty percent of the HbSS children under the age of 1 year were HBsAg-positive as opposed to 4.3% of the control group (chi 2 = 9.1955; P less than 0.001), while 28.6% of patients were HBsAg-positive at the age of 4 years compared with only 7.4% of the controls at the same age. The incidence of anti-HBc in both groups was similar. Markers of HBV infection (HBsAg + anti-HBc) were, however, on the whole higher in the patients with sickle-cell anemia [88/118 (74.6%)] than in the controls [54/88 (61.3%; P less than 0.005)].
对143名6个月至12岁的镰状细胞性贫血患儿进行筛查发现，39.2%的患儿乙肝表面抗原（HBsAg）呈阳性，而在161名同年龄组的对照儿童（血红蛋白基因型为AA）中，这一比例为19.3%（卡方=14.7383；P<0.001）。1岁以下的血红蛋白SS型（HbSS）患儿中，50%的患儿HBsAg呈阳性，而对照组这一比例为4.3%（卡方=9.1955；P<0.001），4岁时，28.6%的患儿HBsAg呈阳性，而同龄对照组中这一比例仅为7.4%。两组中乙肝核心抗体（抗-HBc）的发生率相似。然而，总体而言，镰状细胞性贫血患者中乙肝病毒（HBV）感染标志物（HBsAg+抗-HBc）的比例[88/118（74.6%）]高于对照组[54/88（61.3%；P<0.005）]。
Zotero 插件