Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Addict Biol. 2013 Nov;18(6):897-900. doi: 10.1111/adb.12114.
Ghrelin is a protein that has been given special attention in both nutrition and addiction research during the last decade. Consequently, a vast amount of information has been accumulated concerning the role of ghrelin in natural and drug reward. We are now in the position to ask whether the ghrelin system could be targeted to treat maladaptive behaviours such as obesity and drug addiction. Indeed, ghrelin research has demonstrated that blocking the activity of ghrelin receptors may be effective in reducing the consumption of both food and drugs of abuse. This review will give a short overview of our current knowledge about the ghrelin system in the context of drug and natural rewards as well as the possibility of developing potential ghrelin-based treatments.
在过去的十年中，ghrelin 作为一种蛋白质，受到了营养和成瘾研究的特别关注。因此，积累了大量关于 ghrelin 在自然和药物奖励中的作用的信息。我们现在可以问一下，ghrelin 系统是否可以作为治疗肥胖和药物成瘾等适应不良行为的靶点。事实上，ghrelin 研究表明，阻断 ghrelin 受体的活性可能有效减少食物和滥用药物的消耗。本文综述了我们目前关于 ghrelin 系统在药物和自然奖励中的知识，以及开发潜在的 ghrelin 为基础的治疗方法的可能性。
