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2
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本文引用的文献

1
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.一个具有 GAP 活性的肿瘤抑制复合物，可作用于 Rag GTPases，将氨基酸充足的信号传递给 mTORC1。
Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044.
2
Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.机械刺激通过 ERK 非依赖性机制诱导 mTOR 信号通路：对磷脂酸直接激活 mTOR 的意义。
PLoS One. 2012;7(10):e47258. doi: 10.1371/journal.pone.0047258. Epub 2012 Oct 15.
3
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.Ragulator 是 Rag GTPases 的鸟苷酸交换因子 (GEF)，可将氨基酸水平信号传递给 mTORC1。
Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032.
4
Interactions between exercise and nutrition to prevent muscle waste during ageing.运动与营养相互作用预防衰老过程中的肌肉流失。
Br J Clin Pharmacol. 2013 Mar;75(3):708-15. doi: 10.1111/j.1365-2125.2012.04456.x.
5
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.TBC1D7 是 mTORC1 上游 TSC1-TSC2 复合物的第三个亚基。
Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12.
6
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.质子辅助氨基酸转运蛋白 PAT1 与 Rag GTPases 形成复合物，并在晚期内体和溶酶体膜上激活 TORC1。
PLoS One. 2012;7(5):e36616. doi: 10.1371/journal.pone.0036616. Epub 2012 May 4.
7
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.mTORC1 通过一种需要液泡 H(+)-ATP 酶的内外机制感知溶酶体氨基酸。
Science. 2011 Nov 4;334(6056):678-83. doi: 10.1126/science.1207056.
8
mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.mTORC1 和 mTORC2 相互作用的蛋白使它们的多功能伙伴保持专注。
IUBMB Life. 2011 Oct;63(10):896-914. doi: 10.1002/iub.558. Epub 2011 Sep 9.
9
Blunting of adaptive responses to resistance exercise training in women over 75y.75 岁以上女性对抗阻运动训练的适应反应迟钝。
Exp Gerontol. 2011 Nov;46(11):884-90. doi: 10.1016/j.exger.2011.07.010. Epub 2011 Jul 28.
10
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.哺乳动物雷帕霉素靶蛋白复合物 1 的激活对于必需氨基酸刺激人体骨骼肌蛋白质合成是必需的。
J Nutr. 2011 May;141(5):856-62. doi: 10.3945/jn.111.139485. Epub 2011 Mar 23.

营养物质、激素和运动在骨骼肌中产生的信号的整合。

Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle.

机构信息

Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA.

出版信息

Am J Clin Nutr. 2014 Jan;99(1):237S-242S. doi: 10.3945/ajcn.113.068387. Epub 2013 Nov 27.

DOI:10.3945/ajcn.113.068387
PMID:24284445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3862457/
Abstract

This review focuses on anabolic signaling pathways through which insulin, amino acids, and resistance exercise act to regulate the protein kinase complex referred to as mechanistic target of rapamycin complex (mTORC) 1. Initially, individual pathways through which the 3 anabolic signals act to modulate mTORC1 signaling will be discussed, followed by a summation of evidence showing an additive effect of the regulators. The emphasis will be on mTORC1 signaling in skeletal muscle and its contribution to modulation of rates of protein synthesis. In addition, results from studies using cells in culture will be used to provide a more complete picture of the molecular details of the individual pathways.

摘要

这篇综述主要探讨了胰岛素、氨基酸和抗阻运动通过何种作用机制来调节蛋白激酶复合物，即雷帕霉素靶蛋白复合物 1（mTORC1）。首先，我们将讨论三种合成代谢信号作用于 mTORC1 信号的具体通路，然后总结这些调节因子的协同作用。重点将放在 mTORC1 信号在骨骼肌中的作用以及其对蛋白质合成速率的调控。此外，我们还将使用细胞培养研究结果，更全面地阐述各个通路的分子细节。