营养物质、激素和运动在骨骼肌中产生的信号的整合。
Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle.
机构信息
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA.
出版信息
Am J Clin Nutr. 2014 Jan;99(1):237S-242S. doi: 10.3945/ajcn.113.068387. Epub 2013 Nov 27.
Abstract
This review focuses on anabolic signaling pathways through which insulin, amino acids, and resistance exercise act to regulate the protein kinase complex referred to as mechanistic target of rapamycin complex (mTORC) 1. Initially, individual pathways through which the 3 anabolic signals act to modulate mTORC1 signaling will be discussed, followed by a summation of evidence showing an additive effect of the regulators. The emphasis will be on mTORC1 signaling in skeletal muscle and its contribution to modulation of rates of protein synthesis. In addition, results from studies using cells in culture will be used to provide a more complete picture of the molecular details of the individual pathways.
摘要
这篇综述主要探讨了胰岛素、氨基酸和抗阻运动通过何种作用机制来调节蛋白激酶复合物，即雷帕霉素靶蛋白复合物 1（mTORC1）。首先，我们将讨论三种合成代谢信号作用于 mTORC1 信号的具体通路，然后总结这些调节因子的协同作用。重点将放在 mTORC1 信号在骨骼肌中的作用以及其对蛋白质合成速率的调控。此外，我们还将使用细胞培养研究结果，更全面地阐述各个通路的分子细节。
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Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.哺乳动物雷帕霉素靶蛋白复合物 1 的激活对于必需氨基酸刺激人体骨骼肌蛋白质合成是必需的。
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