Yang Liang, Fang Jiasheng, Liao Daguang, Wang Wei
Department of Neurosurgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410078, P.R. China.
Department of Neurology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Mol Med Rep. 2014 Feb;9(2):567-73. doi: 10.3892/mmr.2013.1827. Epub 2013 Nov 25.
Rapid development of tissue engineering techniques has led to the possibility of treating central nervous injuries with Schwann cells (SCs). However, certain characteristics of SCs, such as a low proliferation ability, greatly restrict their use. The aim of the present study was to investigate whether SCs differentiated from adipose‑derived stem cells (ADSC‑SCs) could used to promote functional recovery in brain contusion in rat. ADSCs were isolated and expanded from the groin of Sprague‑Dawley rats and differentiated into SCs. The ADSC‑SCs were transplanted into the contused rat brain and the locomotor function of the rats was assessed. Significant locomotor function recovery was observed in hemiparalyzed rats treated with ADSCs‑SCs. In conclusion, transplantation of ADSC‑SCs significantly promoted functional recovery following brain contusion.
组织工程技术的快速发展使得利用雪旺细胞（SCs）治疗中枢神经损伤成为可能。然而，SCs的某些特性，如增殖能力低，极大地限制了它们的应用。本研究的目的是探讨从脂肪来源干细胞分化而来的SCs（ADSC-SCs）是否可用于促进大鼠脑挫伤后的功能恢复。从Sprague-Dawley大鼠腹股沟分离并扩增脂肪来源干细胞，然后将其分化为SCs。将ADSC-SCs移植到脑挫伤大鼠脑中，并评估大鼠的运动功能。观察到接受ADSC-SCs治疗的偏瘫大鼠运动功能有显著恢复。总之，ADSC-SCs移植显著促进了脑挫伤后的功能恢复。
